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The Immortal Life of Henrietta Lacks

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Paperback
$18.99 US
On sale Mar 08, 2011 | 400 Pages | 978-1-4000-5218-9
Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the effects of the atom bomb; helped lead to important advances in cloning, in vitro fertilization, and gene mapping; and have been bought and sold by the billions, with devastating consequences for her family.

Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells, from Henrietta’s small, dying hometown of Clover, Virginia—a land of wooden slave quarters, faith healings, and voodoo—to East Baltimore today, where Henrietta’s children, unable to afford health insurance, wrestle with feelings of pride, fear, and betrayal.

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PROLOGUE
The Woman in the Photograph

There’s a photo on my wall of a woman I’ve never met, its left corner torn and patched together with tape. She looks straight into the camera and smiles, hands on hips, dress suit neatly pressed, lips painted deep red. It’s the late 1940s and she hasn’t yet reached the age of thirty. Her light brown skin is smooth, her eyes still young and playful, oblivious to the tumor growing inside her—a tumor that would leave her five children motherless and change the future of medicine. Beneath the photo, a caption says her name is “Henrietta Lacks, Helen Lane or Helen Larson.”
           
No one knows who took that picture, but it’s appeared hundreds of times in magazines and science textbooks, on blogs and laboratory walls. She’s usually identified as Helen Lane, but often she has no name at all. She’s simply called HeLa, the code name given to the world’s first immortal human cells—her cells, cut from her cervix just months before she died.
           
Her real name is Henrietta Lacks.

I’ve spent years staring at that photo, wondering what kind of life she led, what happened to her children, and what she’d think about cells from her cervix living on forever—bought, sold, packaged, and shipped by the trillions to laboratories around the world. I’ve tried to imagine how she’d feel knowing that her cells went up in the first space missions to see what would happen to human cells in zero gravity, or that they helped with some of the most important advances in medicine: the polio vaccine, chemotherapy, cloning, gene mapping, in vitro fertilization. I’m pretty sure that she—like most of us—would be shocked to hear that there are trillions more of her cells growing in laboratories now than there ever were in her body.
            
There’s no way of knowing exactly how many of Henrietta’s cells are alive today. One scientist estimates that if you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—an inconceivable number, given that an individual cell weighs almost nothing. Another scientist calculated that if you could lay all HeLa cells ever grown end-to-end, they’d wrap around the Earth at least three times, spanning more than 350 million feet. In her prime, Henrietta herself stood only a bit over five feet tall.
          
I first learned about HeLa cells and the woman behind them in 1988, thirty-seven years after her death, when I was sixteen and sitting in a community college biology class. My instructor, Donald Defler, a gnomish balding man, paced at the front of the lecture hall and flipped on an overhead projector. He pointed to two diagrams that appeared on the wall behind him. They were schematics of the cell reproduction cycle, but to me they just looked like a neon-colored mess of arrows, squares, and circles with words I didn’t understand, like “MPF Triggering a Chain Reaction of Protein Activations.”
            
I was a kid who’d failed freshman year at the regular public high school because she never showed up. I’d transferred to an alternative school that offered dream studies instead of biology, so I was taking Defler’s class for high-school credit, which meant that I was sitting in a college lecture hall at sixteen with words like mitosis and kinase inhibitors flying around. I was completely lost.
           
“Do we have to memorize everything on those diagrams?” one student yelled.
           
Yes, Defler said, we had to memorize the diagrams, and yes, they’d be on the test, but that didn’t matter right then. What he wanted us to understand was that cells are amazing things: There are about one hundred trillion of them in our bodies, each so small that several thousand could fit on the period at the end of this sentence. They make up all our tissues—muscle, bone, blood—which in turn make up our organs.
           
Under the microscope, a cell looks a lot like a fried egg: It has a white (the cytoplasm) that’s full of water and proteins to keep it fed, and a yolk (the nucleus) that holds all the genetic information that makes you you. The cytoplasm buzzes like a New York City street. It’s crammed full of molecules and vessels endlessly shuttling enzymes and sugars from one part of the cell to another, pumping water, nutrients, and oxygen in and out of the cell. All the while, little cytoplasmic factories work 24/7, cranking out sugars, fats, proteins, and energy to keep the whole thing running and feed the nucleus. The nucleus is the brains of the operation; inside every nucleus within each cell in your body, there’s an identical copy of your entire genome. That genome tells cells when to grow and divide and makes sure they do their jobs, whether that’s controlling your heartbeat or helping your brain understand the words on this page.
            
Defler paced the front of the classroom telling us how mitosis—the process of cell division—makes it possible for embryos to grow into babies, and for our bodies to create new cells for healing wounds or replenishing blood we’ve lost. It was beautiful, he said, like a perfectly choreographed dance.
           
All it takes is one small mistake anywhere in the division process for cells to start growing out of control, he told us. Just one enzyme misfiring, just one wrong protein activation, and you could have cancer. Mitosis goes haywire, which is how it spreads.
           
“We learned that by studying cancer cells in culture,” Defler said. He grinned and spun to face the board, where he wrote two words in enormous print: HENRIETTA LACKS.
          
Henrietta died in 1951 from a vicious case of cervical cancer, he told us. But before she died, a surgeon took samples of her tumor and put them in a petri dish. Scientists had been trying to keep human cells alive in culture for decades, but they all eventually died. Henrietta’s were different: they reproduced an entire generation every twenty-four hours, and they never stopped. They became the first immortal human cells ever grown in a laboratory.
            
“Henrietta’s cells have now been living outside her body far longer than they ever lived inside it,” Defler said. If we went to almost any cell culture lab in the world and opened its freezers, he told us, we’d probably find millions—if not billions—of Henrietta’s cells in small vials on ice.
            
Her cells were part of research into the genes that cause cancer and those that suppress it; they helped develop drugs for treating herpes, leukemia, influenza, hemophilia, and Parkinson’s disease; and they’ve been used to study lactose digestion, sexually transmitted diseases, appendicitis, human longevity, mosquito mating, and the negative cellular effects of working in sewers. Their chromosomes and proteins have been studied with such detail and precision that scientists know their every quirk. Like guinea pigs and mice, Henrietta’s cells have become the standard laboratory workhorse.
            
“HeLa cells were one of the most important things that happened to medicine in the last hundred years,” Defler said.
            
Then, matter-of-factly, almost as an afterthought, he said, “She was a black woman.” He erased her name in one fast swipe and blew the chalk from his hands. Class was over.
           
As the other students filed out of the room, I sat thinking, That’s it? That’s all we get? There has to be more to the story.
           
I followed Defler to his office.
            
“Where was she from?” I asked. “Did she know how important her cells were? Did she have any children?”
            
“I wish I could tell you,” he said, “but no one knows anything about her.”
           
After class, I ran home and threw myself onto my bed with my biology textbook. I looked up “cell culture” in the index, and there she was, a small parenthetical:
In culture, cancer cells can go on dividing indefinitely, if they have a continual supply of nutrients, and thus are said to be “immortal.” A striking example is a cell line that has been reproducing in culture since 1951. (Cells of this line are called HeLa cells because their original source was a tumor removed from a woman named Henrietta Lacks.)

That was it. I looked up HeLa in my parents’ encyclopedia, then my dictionary: No Henrietta.
           
As I graduated from high school and worked my way through college toward a biology degree, HeLa cells were omnipresent. I heard about them in histology, neurology, pathology; I used them in experiments on how neighboring cells communicate. But after Mr. Defler, no one mentioned Henrietta.
           
When I got my first computer in the mid-nineties and started using the Internet, I searched for information about her, but found only confused snippets: most sites said her name was Helen Lane; some said she died in the thirties; others said the forties, fifties, or even sixties. Some said ovarian cancer killed her, others said breast or cervical cancer.
           
Eventually I tracked down a few magazine articles about her from the seventies. Ebony quoted Henrietta’s husband saying, “All I remember is that she had this disease, and right after she died they called me in the office wanting to get my permission to take a sample of some kind. I decided not to let them.” Jet said the family was angry—angry that Henrietta’s cells were being sold for twenty-five dollars a vial, and angry that articles had been published about the cells without their knowledge. It said, “Pounding in the back of their heads was a gnawing feeling that science and the press had taken advantage of them.”
           
The articles all ran photos of Henrietta’s family: her oldest son sitting at his dining room table in Baltimore, looking at a genetics textbook. Her middle son in military uniform, smiling and holding a baby. But one picture stood out more than any other: in it, Henrietta’s daughter, Deborah Lacks, is surrounded by family, everyone smiling, arms around each other, eyes bright and excited. Except Deborah. She stands in the foreground looking alone, almost as if someone pasted her into the photo after the fact. She’s twenty-six years old and beautiful, with short brown hair and catlike eyes. But those eyes glare at the camera, hard and serious. The caption said the family had found out just a few months earlier that Henrietta’s cells were still alive, yet at that point she’d been dead for twenty-five years.
           
All of the stories mentioned that scientists had begun doing research on Henrietta’s children, but the Lackses didn’t seem to know what that research was for. They said they were being tested to see if they had the cancer that killed Henrietta, but according to the reporters, scientists were studying the Lacks family to learn more about Henrietta’s cells. The stories quoted her son Lawrence, who wanted to know if the immortality of his mother’s cells meant that he might live forever too. But one member of the family remained voiceless: Henrietta’s daughter, Deborah.
           
As I worked my way through graduate school studying writing, I became fixated on the idea of someday telling Henrietta’s story. At one point I even called directory assistance in Baltimore looking for Henrietta’s husband, David Lacks, but he wasn’t listed. I had the idea that I’d write a book that was a biography of both the cells and the woman they came from—someone’s daughter, wife, and mother.
           
I couldn’t have imagined it then, but that phone call would mark the beginning of a decadelong adventure through scientific laboratories, hospitals, and mental institutions, with a cast of characters that would include Nobel laureates, grocery store clerks, convicted felons, and a professional con artist. While trying to make sense of the history of cell culture and the complicated ethical debate surrounding the use of human tissues in research, I’d be accused of conspiracy and slammed into a wall both physically and metaphorically, and I’d eventually find myself on the receiving end of something that looked a lot like an exorcism. I did eventually meet Deborah, who would turn out to be one of the strongest and most resilient women I’d ever known. We’d form a deep personal bond, and slowly, without realizing it, I’d become a character in her story, and she in mine.
           
Deborah and I came from very different cultures: I grew up white and agnostic in the Pacific Northwest, my roots half New York Jew and half Midwestern Protestant; Deborah was a deeply religious black Christian from the South. I tended to leave the room when religion came up in conversation because it made me uncomfortable; Deborah’s family tended toward preaching, faith healings, and sometimes voodoo. She grew up in a black neighborhood that was one of the poorest and most dangerous in the country; I grew up in a safe, quiet middle-class neighborhood in a predominantly white city and went to high school with a total of two black students. I was a science journalist who referred to all things supernatural as “woo-woo stuff”; Deborah believed Henrietta’s spirit lived on in her cells, controlling the life of anyone who crossed its paths. Including me.
           
“How else do you explain why your science teacher knew her real name when everyone else called her Helen Lane?” Deborah would say. “She was trying to get your attention.” This thinking would apply to everything in my life: when I married while writing this book, it was because Henrietta wanted someone to take care of me while I worked. When I divorced, it was because she’d decided he was getting in the way of the book. When an editor who insisted I take the Lacks family out of the book was injured in a mysterious accident, Deborah said that’s what happens when you piss Henrietta off.
           
The Lackses challenged everything I thought I knew about faith, science, journalism, and race. Ultimately, this book is the result. It’s not only the story of HeLa cells and Henrietta Lacks, but of Henrietta’s family—particularly Deborah—and their lifelong struggle to make peace with the existence of those cells, and the science that made them possible.
  • WINNER | 2011
    Library of Virginia Literary Award for Nonfiction
  • WINNER | 2011
    Audie Awards
  • WINNER | 2011
    Chicago Public Library and the Chicago Public Library Foundation 21st Century Award
  • WINNER | 2011
    National Academy of Sciences Book Award
  • WINNER | 2011
    Powells 2011 Puddly Award for Nonfiction
  • WINNER | 2011
    Audie Award for Best Nonfiction Audiobook
  • WINNER | 2011
    Ambassador Book Award in American Studies
  • WINNER | 2010
    Goodreads.com Readers Choice Award for Best Debut Author and Best Nonfiction Book of the Year
  • WINNER | 2010
    Medical Journalists' Association Open Book Award, General Readership, Non-Fiction
  • WINNER | 2010
    Wellcome Trust Book Prize
  • WINNER | 2010
    2010 Indie Lit Award for NonFiction
  • WINNER | 2010
    Chicago Tribune Heartland Prize
  • WINNER | 2010
    Bookbrowse.com Diamond Award for Best Book
  • WINNER | 2010
    Audie Awards
  • WINNER | 2010
    American Association for the Advancement of Science's Young Adult Science Book Award
"One of the most graceful and moving nonfiction books I’ve read in a very long time . . . The Immortal Life of Henrietta Lacks . . . floods over you like a narrative dam break, as if someone had managed to distill and purify the more addictive qualities of Erin Brockovich, Midnight in the Garden of Good and Evil and The Andromeda Strain. . . . It feels like the book Ms. Skloot was born to write. It signals the arrival of a raw but quite real talent.”—Dwight Garner, The New York Times

"Skloot's vivid account begins with the life of Henrietta Lacks, who comes fully alive on the page. . . . Immortal Life reads like a novel.”—Eric Roston, The Washington Post

“Gripping . . . by turns heartbreaking, funny and unsettling . . . raises troubling questions about the way Mrs. Lacks and her family were treated by researchers and about whether patients should control or have financial claims on tissue removed from their bodies.”—Denise Grady, The New York Times

The Immortal Life of Henrietta Lacks is a fascinating read and a ringing success. It is a well-written, carefully-researched, complex saga of medical research, bioethics, and race in America. Above all it is a human story of redemption for a family, torn by loss, and for a writer with a vision that would not let go.”—Douglas Whynott, The Boston Globe

"Riveting . . . raises important questions about medical ethics . . . It's an amazing story. . . . Deeply chilling . . . Whether those uncountable HeLa cells are a miracle or a violation, Skloot tells their fascinating story at last with skill, insight and compassion.”—Colette Bancroft, St. Petersburg Times

“The history of HeLa is a rare and powerful combination of race, class, gender, medicine, bioethics, and intellectual property; far more rare is the writer than can so clearly fuse those disparate threads into a personal story so rich and compelling. Rebecca Skloot has crafted a unique piece of science journalism that is impossible to put down—or to forget.”Seed magazine

“No one can say exactly where Henrietta Lacks is buried: during the many years Rebecca Skloot spent working on this book, even Lacks’s hometown of Clover, Virginia, disappeared. But that did not stop Skloot in her quest to exhume, and resurrect, the story of her heroine and her family. What this important, invigorating book lays bare is how easily science can do wrong, especially to the poor. The issues evoked here are giant: who owns our bodies, the use and misuse of medical authority, the unhealed wounds of slavery ... and Skloot, with clarity and compassion, helps us take the long view. This is exactly the sort of story that books were made to tell—thorough, detailed, quietly passionate, and full of revelation.”—TED CONOVER, author of Newjack and The Routes of Man

“It’s extremely rare when a reporter’s passion finds its match in a story. Rarer still when the people in that story courageously join that reporter in the search for what we most need to know about ourselves. When this occurs with a moral journalist who is also a true writer, a human being with a heart capable of holding all of life’s damage and joy, the stars have aligned. This is an extraordinary gift of a book, beautiful and devastating—a work of outstanding literary reportage. Read it! It’s the best you will find in many many years.”—ADRIAN NICOLE LEBLANC, author of Random Family
  
 ”The Immortal Life of Henrietta Lacks brings to mind the work of Philip K. Dick and Edgar Allan Poe. But this tale is true. Rebecca Skloot explores the racism and greed, the idealism and faith in science that helped to save thousands of lives but nearly destroyed a family. This is an extraordinary book, haunting and beautifully told.”—ERIC SCHLOSSER, author of Fast Food Nation 
 
“Skloot’s book is wonderful -- deeply felt, gracefully written, sharply reported. It is a story about science but, much more, about life.”—SUSAN ORLEAN, author of The Orchid Thief
  
“This is a science biography like the world has never seen. What if one of the great American women of modern science and medicine--whose contribution underlay historic discoveries in genetics, the treatment and prevention of disease, reproduction, and the unraveling of the human genome--was a self-effacing African-American tobacco farmer from the Deep South? A devoted mother of five who was escorted briskly to the Jim Crow section of Johns Hopkins for her cancer treatments? What if the untold millions of scientists, doctors, and patients enriched and healed by her gift never, to this day, knew her name? What if her contribution was made without her knowledge or permission? Ladies and gentlemen, meet Henrietta Lacks. Chances are, at the level of your DNA, your inoculations, your physical health and microscopic well-being, you’ve already been introduced.”—Melissa Fay Greene, author of Praying for Sheetrock and There Is No Me Without You
  
“Heartbreaking and powerful, unsettling yet compelling, The Immortal Life of Henrietta Lacks is a richly textured story of the hidden costs of scientific progress. Deftly weaving together history, journalism and biography, Rebecca Skloot?s sensitive account tells of the enduring, deeply personal sacrifice of this African American woman and her family and, at long last, restores a human face to the cell line that propelled 20th century biomedicine. A stunning illustration of how race, gender and disease intersect to produce a unique form of social vulnerability, this is a poignant, necessary and brilliant book.”—Alondra Nelson, Columbia University; editor of Technicolor: Race, Technology and Everyday Life
  
“Rebecca Skloot has written a marvelous book so original that it defies easy description. She traces the surreal journey that a tiny patch of cells belonging to Henrietta Lacks’s body took to the forefront of science. At the same time, she tells the story of Lacks and her family—wrestling the storms of the late twentieth century in America—with rich detail, wit, and humanity. The more we read, the more we realize that these are not two separate stories, but one tapestry. It’s part The Wire, part The Lives of the Cell, and all fascinating.”—Carl Zimmer, author of Microcosm
  
“If virtues could be cultured like cells, Rebecca Skloot’s would be a fine place to start¾a rare combination of compassion, courage, wisdom, and intelligence. This book is extraordinary. As a writer and a human being, Skloot stands way, way out there ahead of the pack.”—MARY ROACH, author of Stiff and Bonk
  
The Immortal Life of Henrietta Lacks takes the reader on a remarkable journey—compassionate, troubling, funny, smart—and irresistible. Along the way, Rebecca Skloot will change the way you see medical science and lead you to wonder who we should value more—the researcher or the research subject? Ethically fascinating and completely engaging—I couldn’t recommend it more.”—DEBORAH BLUM, author of The Poisoner’s Handbook and The Monkey Wars and the Helen Firstbrook Franklin professor of journalism at the University of Wisconsin-Madison
 
 “This remarkable story of how the cervical cells of the late Henrietta Lacks, a poor black woman, enabled subsequent discoveries from the polio vaccine to in vitro fertilization is extraordinary in itself; the added portrayal of Lacks's full life makes the story come alive with her humanity and the palpable relationship between race, science, and exploitation.—PAULA J. GIDDINGS, author of Ida, A Sword Among Lions; Elizabeth A. Woodson 1922 Professor, Afro-American Studies, Smith College
  
“Rebecca Skloot’s steadfast commitment to illuminating the life and contribution of Henrietta Lacks, one of the many vulnerable subjects used for scientific advancement, and the subsequent impact on her family is a testament to the power of solid investigative journalism. Her deeply compelling account of one family’s long and troubled relationship with America’s vast medical-industrial complex is sure to become a cherished classic.”—ALLEN M. HORNBLUM, author of Acres of Skin and Sentenced to Science
 
“Writing with a novelist’s artistry, a biologist’s expertise, and the zeal of an investigative reporter, Skloot tells a truly astonishing story of racism and poverty, science and conscience, spirituality and family driven by a galvanizing inquiry into the sanctity of the body and the very nature of the life force.”Booklist (starred review)
 
“Science journalist Skloot makes a remarkable debut with this multilayered story about ‘faith, science, journalism, and grace.’…Recalls Adrian Nicole LeBlanc’s Random Family…A rich, resonant tale of modern science, the wonders it can perform and how easily it can exploit society’s most vulnerable people.”Publishers Weekly (starred review)
© Manda Townsend

REBECCA SKLOOT is an award-winning science writer whose work has appeared in The New York Times Magazine; O, The Oprah Magazine; Discover; and many others. She is coeditor of The Best American Science Writing 2011 and has worked as a correspondent for NPR’s Radiolab and PBS’s Nova ScienceNOW. She was named one of five surprising leaders of 2010 by the Washington Post. Skloot's debut book, The Immortal Life of Henrietta Lacks, took more than a decade to research and write, and instantly became a New York Times bestseller. It was chosen as a best book of 2010 by more than sixty media outlets, including Entertainment Weekly, People, and the New York Times. It is being translated into more than twenty-five languages, adapted into a young reader edition, and being made into an HBO film produced by Oprah Winfrey and Alan Ball. Skloot is the founder and president of The Henrietta Lacks Foundation. She has a B.S. in biological sciences and an MFA in creative nonfiction. She has taught creative writing and science journalism at the University of Memphis, the University of Pittsburgh, and New York University. She lives in Chicago. For more information, visit her website at RebeccaSkloot.com, where you’ll find links to follow her on Twitter and Facebook. 

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About

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the effects of the atom bomb; helped lead to important advances in cloning, in vitro fertilization, and gene mapping; and have been bought and sold by the billions, with devastating consequences for her family.

Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells, from Henrietta’s small, dying hometown of Clover, Virginia—a land of wooden slave quarters, faith healings, and voodoo—to East Baltimore today, where Henrietta’s children, unable to afford health insurance, wrestle with feelings of pride, fear, and betrayal.

Selected by the following Community Reads programs:
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Excerpt

PROLOGUE
The Woman in the Photograph

There’s a photo on my wall of a woman I’ve never met, its left corner torn and patched together with tape. She looks straight into the camera and smiles, hands on hips, dress suit neatly pressed, lips painted deep red. It’s the late 1940s and she hasn’t yet reached the age of thirty. Her light brown skin is smooth, her eyes still young and playful, oblivious to the tumor growing inside her—a tumor that would leave her five children motherless and change the future of medicine. Beneath the photo, a caption says her name is “Henrietta Lacks, Helen Lane or Helen Larson.”
           
No one knows who took that picture, but it’s appeared hundreds of times in magazines and science textbooks, on blogs and laboratory walls. She’s usually identified as Helen Lane, but often she has no name at all. She’s simply called HeLa, the code name given to the world’s first immortal human cells—her cells, cut from her cervix just months before she died.
           
Her real name is Henrietta Lacks.

I’ve spent years staring at that photo, wondering what kind of life she led, what happened to her children, and what she’d think about cells from her cervix living on forever—bought, sold, packaged, and shipped by the trillions to laboratories around the world. I’ve tried to imagine how she’d feel knowing that her cells went up in the first space missions to see what would happen to human cells in zero gravity, or that they helped with some of the most important advances in medicine: the polio vaccine, chemotherapy, cloning, gene mapping, in vitro fertilization. I’m pretty sure that she—like most of us—would be shocked to hear that there are trillions more of her cells growing in laboratories now than there ever were in her body.
            
There’s no way of knowing exactly how many of Henrietta’s cells are alive today. One scientist estimates that if you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—an inconceivable number, given that an individual cell weighs almost nothing. Another scientist calculated that if you could lay all HeLa cells ever grown end-to-end, they’d wrap around the Earth at least three times, spanning more than 350 million feet. In her prime, Henrietta herself stood only a bit over five feet tall.
          
I first learned about HeLa cells and the woman behind them in 1988, thirty-seven years after her death, when I was sixteen and sitting in a community college biology class. My instructor, Donald Defler, a gnomish balding man, paced at the front of the lecture hall and flipped on an overhead projector. He pointed to two diagrams that appeared on the wall behind him. They were schematics of the cell reproduction cycle, but to me they just looked like a neon-colored mess of arrows, squares, and circles with words I didn’t understand, like “MPF Triggering a Chain Reaction of Protein Activations.”
            
I was a kid who’d failed freshman year at the regular public high school because she never showed up. I’d transferred to an alternative school that offered dream studies instead of biology, so I was taking Defler’s class for high-school credit, which meant that I was sitting in a college lecture hall at sixteen with words like mitosis and kinase inhibitors flying around. I was completely lost.
           
“Do we have to memorize everything on those diagrams?” one student yelled.
           
Yes, Defler said, we had to memorize the diagrams, and yes, they’d be on the test, but that didn’t matter right then. What he wanted us to understand was that cells are amazing things: There are about one hundred trillion of them in our bodies, each so small that several thousand could fit on the period at the end of this sentence. They make up all our tissues—muscle, bone, blood—which in turn make up our organs.
           
Under the microscope, a cell looks a lot like a fried egg: It has a white (the cytoplasm) that’s full of water and proteins to keep it fed, and a yolk (the nucleus) that holds all the genetic information that makes you you. The cytoplasm buzzes like a New York City street. It’s crammed full of molecules and vessels endlessly shuttling enzymes and sugars from one part of the cell to another, pumping water, nutrients, and oxygen in and out of the cell. All the while, little cytoplasmic factories work 24/7, cranking out sugars, fats, proteins, and energy to keep the whole thing running and feed the nucleus. The nucleus is the brains of the operation; inside every nucleus within each cell in your body, there’s an identical copy of your entire genome. That genome tells cells when to grow and divide and makes sure they do their jobs, whether that’s controlling your heartbeat or helping your brain understand the words on this page.
            
Defler paced the front of the classroom telling us how mitosis—the process of cell division—makes it possible for embryos to grow into babies, and for our bodies to create new cells for healing wounds or replenishing blood we’ve lost. It was beautiful, he said, like a perfectly choreographed dance.
           
All it takes is one small mistake anywhere in the division process for cells to start growing out of control, he told us. Just one enzyme misfiring, just one wrong protein activation, and you could have cancer. Mitosis goes haywire, which is how it spreads.
           
“We learned that by studying cancer cells in culture,” Defler said. He grinned and spun to face the board, where he wrote two words in enormous print: HENRIETTA LACKS.
          
Henrietta died in 1951 from a vicious case of cervical cancer, he told us. But before she died, a surgeon took samples of her tumor and put them in a petri dish. Scientists had been trying to keep human cells alive in culture for decades, but they all eventually died. Henrietta’s were different: they reproduced an entire generation every twenty-four hours, and they never stopped. They became the first immortal human cells ever grown in a laboratory.
            
“Henrietta’s cells have now been living outside her body far longer than they ever lived inside it,” Defler said. If we went to almost any cell culture lab in the world and opened its freezers, he told us, we’d probably find millions—if not billions—of Henrietta’s cells in small vials on ice.
            
Her cells were part of research into the genes that cause cancer and those that suppress it; they helped develop drugs for treating herpes, leukemia, influenza, hemophilia, and Parkinson’s disease; and they’ve been used to study lactose digestion, sexually transmitted diseases, appendicitis, human longevity, mosquito mating, and the negative cellular effects of working in sewers. Their chromosomes and proteins have been studied with such detail and precision that scientists know their every quirk. Like guinea pigs and mice, Henrietta’s cells have become the standard laboratory workhorse.
            
“HeLa cells were one of the most important things that happened to medicine in the last hundred years,” Defler said.
            
Then, matter-of-factly, almost as an afterthought, he said, “She was a black woman.” He erased her name in one fast swipe and blew the chalk from his hands. Class was over.
           
As the other students filed out of the room, I sat thinking, That’s it? That’s all we get? There has to be more to the story.
           
I followed Defler to his office.
            
“Where was she from?” I asked. “Did she know how important her cells were? Did she have any children?”
            
“I wish I could tell you,” he said, “but no one knows anything about her.”
           
After class, I ran home and threw myself onto my bed with my biology textbook. I looked up “cell culture” in the index, and there she was, a small parenthetical:
In culture, cancer cells can go on dividing indefinitely, if they have a continual supply of nutrients, and thus are said to be “immortal.” A striking example is a cell line that has been reproducing in culture since 1951. (Cells of this line are called HeLa cells because their original source was a tumor removed from a woman named Henrietta Lacks.)

That was it. I looked up HeLa in my parents’ encyclopedia, then my dictionary: No Henrietta.
           
As I graduated from high school and worked my way through college toward a biology degree, HeLa cells were omnipresent. I heard about them in histology, neurology, pathology; I used them in experiments on how neighboring cells communicate. But after Mr. Defler, no one mentioned Henrietta.
           
When I got my first computer in the mid-nineties and started using the Internet, I searched for information about her, but found only confused snippets: most sites said her name was Helen Lane; some said she died in the thirties; others said the forties, fifties, or even sixties. Some said ovarian cancer killed her, others said breast or cervical cancer.
           
Eventually I tracked down a few magazine articles about her from the seventies. Ebony quoted Henrietta’s husband saying, “All I remember is that she had this disease, and right after she died they called me in the office wanting to get my permission to take a sample of some kind. I decided not to let them.” Jet said the family was angry—angry that Henrietta’s cells were being sold for twenty-five dollars a vial, and angry that articles had been published about the cells without their knowledge. It said, “Pounding in the back of their heads was a gnawing feeling that science and the press had taken advantage of them.”
           
The articles all ran photos of Henrietta’s family: her oldest son sitting at his dining room table in Baltimore, looking at a genetics textbook. Her middle son in military uniform, smiling and holding a baby. But one picture stood out more than any other: in it, Henrietta’s daughter, Deborah Lacks, is surrounded by family, everyone smiling, arms around each other, eyes bright and excited. Except Deborah. She stands in the foreground looking alone, almost as if someone pasted her into the photo after the fact. She’s twenty-six years old and beautiful, with short brown hair and catlike eyes. But those eyes glare at the camera, hard and serious. The caption said the family had found out just a few months earlier that Henrietta’s cells were still alive, yet at that point she’d been dead for twenty-five years.
           
All of the stories mentioned that scientists had begun doing research on Henrietta’s children, but the Lackses didn’t seem to know what that research was for. They said they were being tested to see if they had the cancer that killed Henrietta, but according to the reporters, scientists were studying the Lacks family to learn more about Henrietta’s cells. The stories quoted her son Lawrence, who wanted to know if the immortality of his mother’s cells meant that he might live forever too. But one member of the family remained voiceless: Henrietta’s daughter, Deborah.
           
As I worked my way through graduate school studying writing, I became fixated on the idea of someday telling Henrietta’s story. At one point I even called directory assistance in Baltimore looking for Henrietta’s husband, David Lacks, but he wasn’t listed. I had the idea that I’d write a book that was a biography of both the cells and the woman they came from—someone’s daughter, wife, and mother.
           
I couldn’t have imagined it then, but that phone call would mark the beginning of a decadelong adventure through scientific laboratories, hospitals, and mental institutions, with a cast of characters that would include Nobel laureates, grocery store clerks, convicted felons, and a professional con artist. While trying to make sense of the history of cell culture and the complicated ethical debate surrounding the use of human tissues in research, I’d be accused of conspiracy and slammed into a wall both physically and metaphorically, and I’d eventually find myself on the receiving end of something that looked a lot like an exorcism. I did eventually meet Deborah, who would turn out to be one of the strongest and most resilient women I’d ever known. We’d form a deep personal bond, and slowly, without realizing it, I’d become a character in her story, and she in mine.
           
Deborah and I came from very different cultures: I grew up white and agnostic in the Pacific Northwest, my roots half New York Jew and half Midwestern Protestant; Deborah was a deeply religious black Christian from the South. I tended to leave the room when religion came up in conversation because it made me uncomfortable; Deborah’s family tended toward preaching, faith healings, and sometimes voodoo. She grew up in a black neighborhood that was one of the poorest and most dangerous in the country; I grew up in a safe, quiet middle-class neighborhood in a predominantly white city and went to high school with a total of two black students. I was a science journalist who referred to all things supernatural as “woo-woo stuff”; Deborah believed Henrietta’s spirit lived on in her cells, controlling the life of anyone who crossed its paths. Including me.
           
“How else do you explain why your science teacher knew her real name when everyone else called her Helen Lane?” Deborah would say. “She was trying to get your attention.” This thinking would apply to everything in my life: when I married while writing this book, it was because Henrietta wanted someone to take care of me while I worked. When I divorced, it was because she’d decided he was getting in the way of the book. When an editor who insisted I take the Lacks family out of the book was injured in a mysterious accident, Deborah said that’s what happens when you piss Henrietta off.
           
The Lackses challenged everything I thought I knew about faith, science, journalism, and race. Ultimately, this book is the result. It’s not only the story of HeLa cells and Henrietta Lacks, but of Henrietta’s family—particularly Deborah—and their lifelong struggle to make peace with the existence of those cells, and the science that made them possible.

Awards

  • WINNER | 2011
    Library of Virginia Literary Award for Nonfiction
  • WINNER | 2011
    Audie Awards
  • WINNER | 2011
    Chicago Public Library and the Chicago Public Library Foundation 21st Century Award
  • WINNER | 2011
    National Academy of Sciences Book Award
  • WINNER | 2011
    Powells 2011 Puddly Award for Nonfiction
  • WINNER | 2011
    Audie Award for Best Nonfiction Audiobook
  • WINNER | 2011
    Ambassador Book Award in American Studies
  • WINNER | 2010
    Goodreads.com Readers Choice Award for Best Debut Author and Best Nonfiction Book of the Year
  • WINNER | 2010
    Medical Journalists' Association Open Book Award, General Readership, Non-Fiction
  • WINNER | 2010
    Wellcome Trust Book Prize
  • WINNER | 2010
    2010 Indie Lit Award for NonFiction
  • WINNER | 2010
    Chicago Tribune Heartland Prize
  • WINNER | 2010
    Bookbrowse.com Diamond Award for Best Book
  • WINNER | 2010
    Audie Awards
  • WINNER | 2010
    American Association for the Advancement of Science's Young Adult Science Book Award

Praise

"One of the most graceful and moving nonfiction books I’ve read in a very long time . . . The Immortal Life of Henrietta Lacks . . . floods over you like a narrative dam break, as if someone had managed to distill and purify the more addictive qualities of Erin Brockovich, Midnight in the Garden of Good and Evil and The Andromeda Strain. . . . It feels like the book Ms. Skloot was born to write. It signals the arrival of a raw but quite real talent.”—Dwight Garner, The New York Times

"Skloot's vivid account begins with the life of Henrietta Lacks, who comes fully alive on the page. . . . Immortal Life reads like a novel.”—Eric Roston, The Washington Post

“Gripping . . . by turns heartbreaking, funny and unsettling . . . raises troubling questions about the way Mrs. Lacks and her family were treated by researchers and about whether patients should control or have financial claims on tissue removed from their bodies.”—Denise Grady, The New York Times

The Immortal Life of Henrietta Lacks is a fascinating read and a ringing success. It is a well-written, carefully-researched, complex saga of medical research, bioethics, and race in America. Above all it is a human story of redemption for a family, torn by loss, and for a writer with a vision that would not let go.”—Douglas Whynott, The Boston Globe

"Riveting . . . raises important questions about medical ethics . . . It's an amazing story. . . . Deeply chilling . . . Whether those uncountable HeLa cells are a miracle or a violation, Skloot tells their fascinating story at last with skill, insight and compassion.”—Colette Bancroft, St. Petersburg Times

“The history of HeLa is a rare and powerful combination of race, class, gender, medicine, bioethics, and intellectual property; far more rare is the writer than can so clearly fuse those disparate threads into a personal story so rich and compelling. Rebecca Skloot has crafted a unique piece of science journalism that is impossible to put down—or to forget.”Seed magazine

“No one can say exactly where Henrietta Lacks is buried: during the many years Rebecca Skloot spent working on this book, even Lacks’s hometown of Clover, Virginia, disappeared. But that did not stop Skloot in her quest to exhume, and resurrect, the story of her heroine and her family. What this important, invigorating book lays bare is how easily science can do wrong, especially to the poor. The issues evoked here are giant: who owns our bodies, the use and misuse of medical authority, the unhealed wounds of slavery ... and Skloot, with clarity and compassion, helps us take the long view. This is exactly the sort of story that books were made to tell—thorough, detailed, quietly passionate, and full of revelation.”—TED CONOVER, author of Newjack and The Routes of Man

“It’s extremely rare when a reporter’s passion finds its match in a story. Rarer still when the people in that story courageously join that reporter in the search for what we most need to know about ourselves. When this occurs with a moral journalist who is also a true writer, a human being with a heart capable of holding all of life’s damage and joy, the stars have aligned. This is an extraordinary gift of a book, beautiful and devastating—a work of outstanding literary reportage. Read it! It’s the best you will find in many many years.”—ADRIAN NICOLE LEBLANC, author of Random Family
  
 ”The Immortal Life of Henrietta Lacks brings to mind the work of Philip K. Dick and Edgar Allan Poe. But this tale is true. Rebecca Skloot explores the racism and greed, the idealism and faith in science that helped to save thousands of lives but nearly destroyed a family. This is an extraordinary book, haunting and beautifully told.”—ERIC SCHLOSSER, author of Fast Food Nation 
 
“Skloot’s book is wonderful -- deeply felt, gracefully written, sharply reported. It is a story about science but, much more, about life.”—SUSAN ORLEAN, author of The Orchid Thief
  
“This is a science biography like the world has never seen. What if one of the great American women of modern science and medicine--whose contribution underlay historic discoveries in genetics, the treatment and prevention of disease, reproduction, and the unraveling of the human genome--was a self-effacing African-American tobacco farmer from the Deep South? A devoted mother of five who was escorted briskly to the Jim Crow section of Johns Hopkins for her cancer treatments? What if the untold millions of scientists, doctors, and patients enriched and healed by her gift never, to this day, knew her name? What if her contribution was made without her knowledge or permission? Ladies and gentlemen, meet Henrietta Lacks. Chances are, at the level of your DNA, your inoculations, your physical health and microscopic well-being, you’ve already been introduced.”—Melissa Fay Greene, author of Praying for Sheetrock and There Is No Me Without You
  
“Heartbreaking and powerful, unsettling yet compelling, The Immortal Life of Henrietta Lacks is a richly textured story of the hidden costs of scientific progress. Deftly weaving together history, journalism and biography, Rebecca Skloot?s sensitive account tells of the enduring, deeply personal sacrifice of this African American woman and her family and, at long last, restores a human face to the cell line that propelled 20th century biomedicine. A stunning illustration of how race, gender and disease intersect to produce a unique form of social vulnerability, this is a poignant, necessary and brilliant book.”—Alondra Nelson, Columbia University; editor of Technicolor: Race, Technology and Everyday Life
  
“Rebecca Skloot has written a marvelous book so original that it defies easy description. She traces the surreal journey that a tiny patch of cells belonging to Henrietta Lacks’s body took to the forefront of science. At the same time, she tells the story of Lacks and her family—wrestling the storms of the late twentieth century in America—with rich detail, wit, and humanity. The more we read, the more we realize that these are not two separate stories, but one tapestry. It’s part The Wire, part The Lives of the Cell, and all fascinating.”—Carl Zimmer, author of Microcosm
  
“If virtues could be cultured like cells, Rebecca Skloot’s would be a fine place to start¾a rare combination of compassion, courage, wisdom, and intelligence. This book is extraordinary. As a writer and a human being, Skloot stands way, way out there ahead of the pack.”—MARY ROACH, author of Stiff and Bonk
  
The Immortal Life of Henrietta Lacks takes the reader on a remarkable journey—compassionate, troubling, funny, smart—and irresistible. Along the way, Rebecca Skloot will change the way you see medical science and lead you to wonder who we should value more—the researcher or the research subject? Ethically fascinating and completely engaging—I couldn’t recommend it more.”—DEBORAH BLUM, author of The Poisoner’s Handbook and The Monkey Wars and the Helen Firstbrook Franklin professor of journalism at the University of Wisconsin-Madison
 
 “This remarkable story of how the cervical cells of the late Henrietta Lacks, a poor black woman, enabled subsequent discoveries from the polio vaccine to in vitro fertilization is extraordinary in itself; the added portrayal of Lacks's full life makes the story come alive with her humanity and the palpable relationship between race, science, and exploitation.—PAULA J. GIDDINGS, author of Ida, A Sword Among Lions; Elizabeth A. Woodson 1922 Professor, Afro-American Studies, Smith College
  
“Rebecca Skloot’s steadfast commitment to illuminating the life and contribution of Henrietta Lacks, one of the many vulnerable subjects used for scientific advancement, and the subsequent impact on her family is a testament to the power of solid investigative journalism. Her deeply compelling account of one family’s long and troubled relationship with America’s vast medical-industrial complex is sure to become a cherished classic.”—ALLEN M. HORNBLUM, author of Acres of Skin and Sentenced to Science
 
“Writing with a novelist’s artistry, a biologist’s expertise, and the zeal of an investigative reporter, Skloot tells a truly astonishing story of racism and poverty, science and conscience, spirituality and family driven by a galvanizing inquiry into the sanctity of the body and the very nature of the life force.”Booklist (starred review)
 
“Science journalist Skloot makes a remarkable debut with this multilayered story about ‘faith, science, journalism, and grace.’…Recalls Adrian Nicole LeBlanc’s Random Family…A rich, resonant tale of modern science, the wonders it can perform and how easily it can exploit society’s most vulnerable people.”Publishers Weekly (starred review)

Author

© Manda Townsend

REBECCA SKLOOT is an award-winning science writer whose work has appeared in The New York Times Magazine; O, The Oprah Magazine; Discover; and many others. She is coeditor of The Best American Science Writing 2011 and has worked as a correspondent for NPR’s Radiolab and PBS’s Nova ScienceNOW. She was named one of five surprising leaders of 2010 by the Washington Post. Skloot's debut book, The Immortal Life of Henrietta Lacks, took more than a decade to research and write, and instantly became a New York Times bestseller. It was chosen as a best book of 2010 by more than sixty media outlets, including Entertainment Weekly, People, and the New York Times. It is being translated into more than twenty-five languages, adapted into a young reader edition, and being made into an HBO film produced by Oprah Winfrey and Alan Ball. Skloot is the founder and president of The Henrietta Lacks Foundation. She has a B.S. in biological sciences and an MFA in creative nonfiction. She has taught creative writing and science journalism at the University of Memphis, the University of Pittsburgh, and New York University. She lives in Chicago. For more information, visit her website at RebeccaSkloot.com, where you’ll find links to follow her on Twitter and Facebook. 

View titles by Rebecca Skloot

Media

The Official Book Trailer

Guides

Educator Guide for The Immortal Life of Henrietta Lacks

Classroom-based guides appropriate for schools and colleges provide pre-reading and classroom activities, discussion questions connected to the curriculum, further reading, and resources.

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First-Year Reading (FYR) Guide for The Immortal Life of Henrietta Lacks

Designed specifically to be used by faculty or program facilitators for college First-Year Common Reading programs.

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Discussion Guide for The Immortal Life of Henrietta Lacks

Provides questions, discussion topics, suggested reading lists, introductions and/or author Q&As, which are intended to enhance reading groups’ experiences.

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